Bernd Kaina Selected Research

O-(6)-methylguanine

4/2022	Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells.
12/2021	Accumulation of Temozolomide-Induced Apoptosis, Senescence and DNA Damage by Metronomic Dose Schedule: A Proof-of-Principle Study with Glioblastoma Cells.
7/2021	Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment.
1/2019	DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas.
11/2013	Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.
1/2013	Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.
6/2011	Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.
1/2011	Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.
1/2009	Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.
2/2006	O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.

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Bernd Kaina Research Topics

Disease

93	Neoplasms (Cancer) 04/2022 - 03/2002
33	Glioma (Gliomas) 12/2021 - 02/2006
29	Glioblastoma (Glioblastoma Multiforme) 04/2022 - 02/2006
17	Chromosome Aberrations (Chromosome Abnormalities) 12/2016 - 01/2002
10	Necrosis 03/2021 - 08/2002
9	Brain Neoplasms (Brain Tumor) 04/2022 - 07/2009
9	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 11/2013
9	Carcinogenesis 01/2021 - 02/2004
9	Melanoma (Melanoma, Malignant) 08/2017 - 10/2009
6	Neoplasm Metastasis (Metastasis) 10/2020 - 01/2004
5	Inflammation (Inflammations) 01/2021 - 08/2007
5	Ataxia Telangiectasia (Louis Bar Syndrome) 05/2015 - 09/2006
5	Carcinoma (Carcinomatosis) 07/2010 - 01/2004
4	Hypersensitivity (Allergy) 09/2010 - 11/2003
4	Leukemia 09/2006 - 01/2003
3	Astrocytoma (Pilocytic Astrocytoma) 01/2019 - 10/2004
3	Genomic Instability 01/2017 - 05/2002
3	Breast Neoplasms (Breast Cancer) 11/2016 - 07/2010
3	Malaria 10/2016 - 05/2010
3	Colonic Neoplasms (Colon Cancer) 05/2015 - 01/2003
3	Testicular Neoplasms (Testicular Cancer) 12/2010 - 10/2003
2	Pain (Aches) 03/2021 - 09/2020
2	Papilloma (Papillomatosis) 03/2014 - 03/2003
2	Blister (Bulla) 07/2007 - 03/2005
2	Lymphoma (Lymphomas) 03/2005 - 01/2004
2	Chromosome Breakage 08/2002 - 03/2002

Drug/Important Bio-Agent (IBA)

43	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2002
40	Temozolomide (Temodar)FDA LinkGeneric 04/2022 - 11/2004
27	Proteins (Proteins, Gene)FDA Link 04/2019 - 03/2002
25	Pharmaceutical PreparationsIBA 04/2022 - 03/2005
20	Alkylating AgentsIBA 11/2019 - 04/2003
13	O-(6)-methylguanineIBA 04/2022 - 03/2003
13	MethyltransferasesIBA 01/2021 - 10/2003
10	O(6)-Methylguanine-DNA MethyltransferaseIBA 01/2016 - 03/2003
9	Small Interfering RNA (siRNA)IBA 10/2015 - 12/2007
8	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2018 - 12/2007
8	fotemustine (Muphoran)IBA 08/2017 - 11/2004
8	NimustineIBA 08/2017 - 12/2007
8	CarcinogensIBA 08/2017 - 10/2003
8	Cisplatin (Platino)FDA LinkGeneric 05/2013 - 12/2004
6	EnzymesIBA 01/2018 - 02/2006
6	GuanineIBA 01/2011 - 10/2003
5	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2020 - 10/2002
5	ArtesunateIBA 10/2016 - 10/2004
5	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2012 - 01/2004
4	A-Form DNA (A-DNA)IBA 04/2022 - 02/2006
4	Phosphotransferases (Kinase)IBA 12/2017 - 12/2004
4	Glucose (Dextrose)FDA LinkGeneric 10/2017 - 11/2004
4	Carmustine (FIVB)FDA Link 08/2017 - 12/2007
4	Lomustine (CCNU)FDA Link 08/2017 - 10/2014
4	Messenger RNA (mRNA)IBA 08/2013 - 05/2012
4	Lovastatin (Mevacor)FDA LinkGeneric 01/2011 - 10/2002
3	Cytostatic AgentsIBA 12/2021 - 03/2002
3	AzoxymethaneIBA 01/2021 - 12/2010
3	DNA Repair EnzymesIBA 01/2021 - 03/2002
3	DNA AdductsIBA 08/2017 - 11/2010
3	Indicators and Reagents (Reagents)IBA 02/2017 - 07/2010
3	Transcription Factors (Transcription Factor)IBA 10/2015 - 02/2004
3	SmokeIBA 08/2015 - 07/2010
3	Environmental CarcinogensIBA 10/2013 - 01/2004
3	SurvivinIBA 01/2013 - 01/2010
3	Topotecan (Hycamtin)FDA LinkGeneric 01/2013 - 10/2005
3	Methylnitronitrosoguanidine (MNNG)IBA 11/2010 - 04/2004
3	Cantharidin (Cantharides)IBA 08/2007 - 03/2005
2	Histones (Histone)IBA 04/2022 - 10/2020
2	Biological ProductsIBA 10/2021 - 01/2019
2	CurcuminIBA 07/2021 - 01/2021
2	Analgesics (Analgesic Drugs)IBA 03/2021 - 09/2020
2	Methadone (Dolophine)FDA LinkGeneric 03/2021 - 09/2020
2	IronIBA 01/2021 - 10/2004
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2021 - 01/2018
2	Dextrans (Dextran)FDA Link 01/2021 - 01/2018
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2018 - 02/2006
2	1-(2-chloroethyl)-1-nitrosourea (CNU)IBA 08/2017 - 11/2016
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2017 - 08/2004
2	Caspase 3 (Caspase-3)IBA 04/2017 - 03/2002
2	Biomarkers (Surrogate Marker)IBA 11/2016 - 10/2003
2	Valproic Acid (Depakote)FDA LinkGeneric 01/2016 - 06/2011
2	Histone Deacetylase InhibitorsIBA 01/2016 - 06/2011
2	Caspase 9IBA 10/2015 - 03/2002
2	Thioctic Acid (Lipoic Acid)IBA 10/2015 - 08/2015
2	Nitroso CompoundsIBA 10/2015 - 11/2013
2	Topoisomerase II InhibitorsIBA 05/2015 - 12/2008
2	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 07/2014 - 07/2010
2	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 03/2014 - 03/2003
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 04/2013 - 08/2010
2	Topoisomerase I InhibitorsIBA 01/2013 - 01/2010
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 01/2013 - 12/2008
2	AnthracyclinesIBA 05/2012 - 01/2003
2	ArtemisininsIBA 05/2010 - 10/2004
2	artemisinin (artemisinine)IBA 06/2008 - 10/2004
2	Arsenic Trioxide (Trisenox)FDA Link 08/2007 - 09/2004
2	O(6)-benzylguanineIBA 03/2007 - 02/2006
2	E-SelectinIBA 08/2004 - 01/2004
1	Antineoplastic Agents (Antineoplastics)IBA 10/2021

Therapy/Procedure

56	Therapeutics 12/2021 - 10/2002
18	Drug Therapy (Chemotherapy) 10/2021 - 03/2005
7	Radiotherapy 12/2017 - 08/2004
5	Chinese Traditional Medicine (Traditional Chinese Medicine) 12/2011 - 07/2007
2	Aftercare (After-Treatment) 07/2014 - 01/2014